{"id":105910,"date":"2025-02-04T11:21:26","date_gmt":"2025-02-04T17:21:26","guid":{"rendered":"https:\/\/engineering.wisc.edu\/?post_type=tribe_events&p=105910"},"modified":"2025-02-11T13:16:59","modified_gmt":"2025-02-11T19:16:59","slug":"bme-seminar-series-arash-farhad-phd","status":"publish","type":"tribe_events","link":"https:\/\/engineering.wisc.edu\/event\/bme-seminar-series-arash-farhad-phd\/","title":{"rendered":"BME Seminar Series: Arash Farhad, PhD"},"content":{"rendered":"
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Engineering multistate trackable cells for smart precision therapeutics<\/h2>\n\n\n\n
\"Arash<\/figure>\n\n\n\n

Arash Farhadi, PhD
Postdoctoral Scholar
Voigt Lab
Massachusetts Institute of Technology<\/strong><\/p>\n\n\n\n

Abstract:
The engineering of immune cells and microbes into living therapeutics is emerging as a powerful approach for treating many diseases. However, two key challenges must be addressed to unlock the full potential of living therapeutics: intricately programming cells to perform diverse therapeutic tasks, and effectively monitoring them once administered to the body. My research provides the foundation to address these major challenges. In my presentation, I will outline how cells can be engineered to differentiate into multistate communities with distributed functions, using Synthetic Differentiation circuits. The biomolecular mechanism of Synthetic Differentiation circuits can be engineered to tune the community composition, expand the number of unique states, and replenish population imbalances in the community. I will highlight examples demonstrating the versatility of these circuits in applications spanning living therapeutics and agricultural biotechnology. Additionally, I will demonstrate noninvasive methods for tracking the location and function of cells deep in the body. Most methods to image cells rely on light, which has limited penetration depth. Conversely, ultrasound can image deep in tissue but lacks genetic reporters. I will introduce the first acoustic reporter genes (ARGs)\u2014a ‘GFP’ for ultrasound\u2014that enable imaging of cells and their gene expression inside the living, intact animal. Together, these technologies will enable next-generation living therapeutics capable of simultaneously targeting many disease hallmarks while providing real-time feedback to scientists and clinicians.<\/p>\n\n\n\n

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